Chapter 5

Leptaden for absence or deficiency of Lactation, High Risk Pregnancies

In Silico Studies
UNVEILING THE GALACTAGOGUE MECHANISM OF LEPTADENIA RETICULATA ACTIVE COMPONENTS: IN-SILICO MOLECULAR DOCKING STUDIES ON DOPAMINE, OXYTOCIN, AND THYROID HORMONE RECEPTORS

by Mr. Nachiket Atale (MSc.), Mr. Tushar Gaikwad (MSc.), Mr. Sarvesh Turambekar (MSc.), Dr. Ulhas Patil (PhD.), Dr. Rajendra Choure (PhD.), Microbiology Department, The Institute of Science, Dr. Homi Bhabha State University, Mumbai, 400032

In Silico Studies
Molecular docking and dynamics reveal potential galactagogue mechanism of Breynia patens via D2R, OXTR, and TRβ modulation

by Mr. Tushar Gaikwad (MSc.PhD Scholar), Mr. Nachiket Atale (MSc.PhD Scholar), Dr. Rajendra Choure (PhD.), Dr. Ulhas Patil (PhD.) Microbiology Department, The Institute of Science, Dr. Homi Bhabha State University, Mumbai, 400032University, Mumbai, 400032

Study of composition of breast milk and the effect of Leptaden on the quality of breast milk
Dr. B.N.Purandare, MD,FRCS,FRCOG, FICS, FCPS, FAMS ; Dr. Mrs. Manda Purandare, MD,DGO,DFP ; Dr. N.M.Purandare, MD(Path), Post-Grad inst. (for study and research) in Gynecology. Wadia Maternity Hospital, Bombay
CV International Congress of Pediatrics, Oct 1977 New Delhi

Leptaden- A herbal drug in lactation and pregnancy – Review of 20 clinical trials by 40 senior gynecologists
Dr. Mrs. A. Padma Rao, MD, DGO, Prof & Director of PG inst of O & G, Kasturba Medical College Hospital, Manipal, Karnataka
4th World Congress on human reproduction, Nov-Dec 1983 Bombay India.

Leptaden – A non hormonal Ayurvedic drug for deficient lactation in mothers of an urban community ( A double blind clinical trial)
Dr. Bhupendra C. Patel, MD,DGO; Dr. Manoj V. Parikh MD, DGO, Dr. Mrs. Leelaben B. Patel MD, DGO
7th All Gujarat Obst & Gynaec congress, Rajkot, Nov 1981 ; Medicine & Surgery, Vol XXII:6, June 1982.

A controlled trial of Leptaden in lactation failure and an experimental study in lactating rats
Dr. Kasturi Lal, MS, DGO, FICS ; Dr. Bhupinder Singh, MSc, DBA, Dr. Yudhishter VirGupta, MBBS ; Dr. C.N. Tiku, MBBS Mr. D.S. Agarwal , Msc, Lecturer 22nd All india O & G congress, indore, Dec 1978 ; Indian Practitioner vol XXXIII(10), Oct 1980

A controlled trial on Leptaden in weight gain of infants as a galactogogue in lactation cases
Dr. Prof. N.R.Bhandari, MD(Ped), MAMS, FIAP, DCH ; Dr. S.L. Soni, MBBS, DCH, Dept of Pead., Gandhi Medical College, Bhopal , MP
Indian Practitioner, 32:4, April 1979.

Effect of Leptaden on Lactation ( A controlled clinical study)
Dr. Prof. A. Padma Rao, MD, DGO, Dr H.I.Devi, MBBS, DGO, Kasturba Medical College Hospital, Manipla , Karnataka
Antiseptic, 74:7, July 1977.

Lactation – A clinical trial with Leptaden a Herbal Drug
Dr. Kusum Gupta, MS, Dr. Prof. Naval Kishore, MS, FACS, head of dept. of O & G, SN Medical College, Agra(UP)
Antiseptic, 63:10, Oct 1966.

Mystery of Lactation (A Clinical study on an Indian drug)
Dr. Miss Malati R. Deshpande, MBBS, DGO, MRCP, (Endocrinology), Dr. Manju N. Asher, GFAM, Bombay
Antiseptic, 59:11, Nov 1962.

Studies On Lactogenic Property Of Leptadenia Reticulata (Jivanti) And Leptaden Tablets In Goats, Sheep, Cows And Buffaloes
J. V. Anjaria And Indra Gupta
Department of Pharmacology, Gujarat College of Veterinary Science and Animal Husbandry, Anand, Gujarat.Department of Pharmacology, U.P. College of Veterinary Science and Animal Husbandry. Matbura U.P.

Study of composition of breast milk and the effect of Leptaden on the quality of breast milk
Dr. B.N.Purandare, MD,FRCS,FRCOG, FICS, FCPS, FAMS ; Dr. Mrs. Manda Purandare, MD,DGO,DFP ; Dr. N.M.Purandare, MD(Path), Post-Grad inst. (for study and research) in Gynecology. Wadia Maternity Hospital, Bombay
CV International Congress of Pediatrics, Oct 1977 New Delhi

Leptaden- A herbal drug in lactation and pregnancy – Review of 20 clinical trials by 40 senior gynecologists
Dr. Mrs. A. Padma Rao, MD, DGO, Prof & Director of PG inst of O & G, Kasturba Medical College Hospital, Manipal, Karnataka
4th World Congress on human reproduction, Nov-Dec 1983 Bombay India.

Leptaden – A non hormonal Ayurvedic drug for deficient lactation in mothers of an urban community ( A double blind clinical trial)
Dr. Bhupendra C. Patel, MD,DGO; Dr. Manoj V. Parikh MD, DGO, Dr. Mrs. Leelaben B. Patel MD, DGO
7th All Gujarat Obst & Gynaec congress, Rajkot, Nov 1981 ; Medicine & Surgery, Vol XXII:6, June 1982.

A controlled trial of Leptaden in lactation failure and an experimental study in lactating rats
Dr. Kasturi Lal, MS, DGO, FICS ; Dr. Bhupinder Singh, MSc, DBA, Dr. Yudhishter VirGupta, MBBS ; Dr. C.N. Tiku, MBBS Mr. D.S. Agarwal , Msc, Lecturer 22nd All india O & G congress, indore, Dec 1978 ; Indian Practitioner vol XXXIII(10), Oct 1980

A controlled trial on Leptaden in weight gain of infants as a galactogogue in lactation cases
Dr. Prof. N.R.Bhandari, MD(Ped), MAMS, FIAP, DCH ; Dr. S.L. Soni, MBBS, DCH, Dept of Pead., Gandhi Medical College, Bhopal , MP
Indian Practitioner, 32:4, April 1979.

Effect of Leptaden on Lactation ( A controlled clinical study)
Dr. Prof. A. Padma Rao, MD, DGO, Dr H.I.Devi, MBBS, DGO, Kasturba Medical College Hospital, Manipla , Karnataka
Antiseptic, 74:7, July 1977.

Breast Feeding and Leptaden
Dr. Mrs. Jyoti M. Kothari, MD, DGO ; Dr. Miss Meena L. Kothari, MBBS, DGO, Ramkrishna Mission hospital, Bombay
48th All India Medical Conference, Ahmedabad, Dec 1972.

Lactation – A clinical trial with Leptaden a Herbal Drug
Dr. Kusum Gupta, MS, Dr. Prof. Naval Kishore, MS, FACS, head of dept. of O & G, SN Medical College, Agra(UP)
Antiseptic, 63:10, Oct 1966.

A herbal drug that stimulates lactation
Dr. Malati G. Gokhale, MD, Conslt. O&G, jagjivan Ram western Hosp., Hon O&G, Ayurvedic Rugnalay Hospital, RV Ayurvedic Hosp., Sion, Bombay
Indian Practitioner, 18:12, 1965.

Mystery of Lactation (A Clinical study on an Indian drug)
Dr. Miss Malati R. Deshpande, MBBS, DGO, MRCP, (Endocrinology), Dr. Manju N. Asher, GFAM, Bombay
Antiseptic, 59:11, Nov 1962.

A possible mechanism of leptaden action by inhibiting prostaglandin F2 alpha synthesis
Dr.S.C. Sharma, Phd, Lecturer, Trinity college, Dublin-2, Ireland
Indian Journal of medical research 64:4, 1976.

Effect of Leptaden on smooth muscles pretreated with some antihistaminic and atropine
Dr. K.Sambasiva Rao and Dr. M. Krishnamurthy, College of Vet. Sciences, hyderbad, AP
Indian Vet Hournal, 53:5, May 1976.

Pharmacological studies on indegenous drugs Leptadenia Reticulata and Breynia Patens
Dr. P.N.Shrivastava, MVSc, Dr. D.N.Shrivastava, MVSc, Jawaharlal Neru Krishi Vidyalaya, Jabalpur, MP Prof. A.H.Ahmed, PhD, Head of dept of pharmacology, haryana agriculture univ, Hissar, Haryana
Indian Vet Journal 51, Aug 1974.

Leptaden on milk yield in the Lactating Rats
Dr. S.C. Sharma, BVSc, & AH, Dept. of pharmacology, PGI Chandigarh
19th Indian Veterinary conference, Ranchi, May 1970.

Studies of Leptadenia Reticulata – Pharmacological actions of aqueous extract (independent study from dept of pharmacology)
Dr. S.L. Agarwal, Dr. B.S. Deshmankar, Dr. S.C.L. Verma, Dr. S.P.Saxena, Dept of pharmacology, GR Medical College Gwalior
Indian Journal of medical research 48:7, July 1960.