ALOES COMPOUND* IN STERILITY
(A Review of 797 cases)
Dr. A.V. Sangamnerkar, M.D., D.G.O
Consulting Obsletrician&Gynaecologist,
Colony Nursing Home, 209, Sadashiv Peth, POONA 411 030.
INTRODUCTION
Sterility
is a most perplexing problem for Gynecologist, General Practitioner and for patients
also. From years together various efforts have been made to satisfy the urge of
a couple to have an offspring. But with all the efforts till this day and
recent advances in medical Science an absolute answer to all the cases of Infertility
is not found.
Various
tests, investigations etc. have been devised and these are useful to many of
them where the organic and pathological causes are detected. But all the same
there is large number of infertility cases where in no specific defect is
detected by all the routine investigations done on the couple. In other words,
they are found normal but still are having the curse of infertility.
Infertility
is usually defined as 1 year of unprotected coitus without Pregnancy. Accordingly
10 to 20% couples are considered as infertile. Statistically,
1.
Male
Factors are responsible for 40%
2.
Failure
of ovulation 10 to 15%
3.
Tubal
Pathology 20 to 30%
4.
Cervical
factor 5%
5.
No
known cause cases 10 to 20%
These 10 to
20% of the couples without any organic pathology are the real hard nuts to
break. And it is for these cases that the drug Aloes Compound has been tried as
an adjuvant therapy to antibiotics, anti-inflammatory drugs and to hormone
preparations and also in cases where the menstrual cycle was scanty, irregular.
Sharma
(1972) in his pharmacological control study on female Rabbits of known
fertility observed that Aloes Compound has a fertility promoting property.
Roshan Bulsara
(1966) used Aloes Compound along with Lugol's Iodine in cases of infertility
associated with scanty and irregular menses and found it satisfactory.
Pharmacology
and properties Aloes Compound:-
1.
ALOES: (Aloes Indica): 70 mg: is obtained from sap of leaves cut from the aloes plant and has
crystalline aloin, aloe emodin, resin and volatie oil etc. constituents. It is
bitter, appetizer, digestive, laxative and emmenagogue. Used in delayed or
irregular menstruation occurring at the interval of two or three months, Aloes
gives better results when given in combination with Myrrh.
2.
MYRRH (Hira Bol): 70 mg: hematinic, appetizer and emmenagogue; excreted by the mucous
membrane of the genito-urinary tract which it stimulates, disinfects and regulates.
Used in amenorrhea due to anaemia with iron bhasma, painful and scanty
menstruation. *
3.
JEEVANTI (Leptadenia reticulata): Kamboji (Breynia patens): 60 mg: Stabilizing effect
of neuro-glandular system.
4.
MANJISHTA (Rubiacordifolia): 35 mg. Sedative, anti-inflammatory, tonic. It
acts on uterine muscles through the nervous system. Used in scanty
menstruation, amenorrhoea after delivery, endometritis.
5.
KASIS BHASMA (Iron Bhasma): 30 mg:
preparation
of established value for anaemia and debility without the side effects ol the
usual iron-therapy like constipation and blackening of teeth. Used along with
Myrrh in irregular menstruation due to anaemia. By improving anaemia it helps
in regularising menstruation.
6.
HURMAL (Paganum harmala): 35 mg: antispasmodic sedative and
emmenagogue. Used in amenorrhoea, dysmenorrhoea.
Here we
have considered Aloes Compoundfor its
anabolic activity in the genital tract/ uterine and ovarian function.
MATERIAL
& METHODS:
A study of 797 cases of Primary & Secondary infertility who have
visited the clinic between January 71 to December 76 was undertaken. Details
are as follows:
TABLE
1 No. of cases reviewed &
evaluated
No. of Total cases reviewed 797
No. of cases dropped after first
consultation 263
Inadequate following 177
Total No. of cases evaluated 357
357 = 306 Primary + 51 Secondary Infertility.
|
TABLE No. 2: Age
Group |
||||
|
|
||||
|
Age |
Primary |
% |
Secondary |
% |
|
Below 20 |
9.1% |
2 |
3.9% |
|
|
20 to 30 |
216 |
70.6% |
33 |
64.7% |
|
31 to 40, |
60 |
19 6% |
16 |
31.4% |
|
above 40 |
2 |
0.7% |
- |
- |
|
Total |
306 |
100.0% |
51 |
100,0% |
R. COMPOUND V/S Oxyphenbutazone Aspirin
"in ACUTE SOFT TISSUE TRAUMA"
|
Tenderness over the
sprained and contused part disappeared within the 1st week in those
receiving |
"in ACUTE SOFT TISSUE
TRAUMA"
a Clinical Trial of R.Compound
by
Dr. L.V. Raghava Rao, M.S.,
Assistant Prof. in Orthopaedics
Kasturba Medical College, Manipal (Karnataka)
Paper at : Karnataka Orthopaedic Conference,
Manipal, Feb. 1976
Acute soft
tissue trauma in the form of sprains and contusions is of very common
occurrence. Numerous anti-inflammatories, analgesic drugs are available,
ranging from the basic aspirin to the phenylbutazone group, indomethacin and
ibuprofen, with their corresponding side effects. The Ayurvedic durg,
R. Compound (Alarsin) is said to be having anti-inflammatory and analgesic
activities comparable to hydrocortisone and butazolidine without any toxic
effects even on prolonged use.
The present
trial is designed to study the anti-inflammatory & analgesic properties of
R. Compound as compared to two other commonly used anti-inflammatory &
analgesic drugs, oxyphenbutazone and aspirin.
MATERIAL
AND METHODS
Thirty ambulatories otherwise healthy patients with acute soft tissue
trauma in the form of sprains, contusions, hemarthrosis knee and traumatic
synovitis were selected for this study, from the out-patient Department of
K.M.C. Hospital, Manipal. There were 18 men and 12 women. All these cases were
radiologically studied to eliminate any fractures. These patients were divided
into three groups of 10 each. Group I patients received R. Compound at a dose
of 1 tab/three times a day. Group II patients received oxyphenbutazone
(Tanderil - Geigy, Oxyrin - Themis) at a dose of 1 tab/ tds. Group III patients
received Aspirin at adose of 2 tab/tds. Side effects if any were noted. In all
these cases, treatment was instituted within 18 hours. (None of these cases
had any associated diseases).
CASES
ACCORDING TO DIAGNOSIS
Sprains around the ankle - 8
Sprains of wrist - 4
Hemarthrosis, knee - 3
Traumatic Synovitis - 4
Contusions - 11
-------------------
TOTAL 30
ADDITIONAL TREATMENT
All these cases were advised to take suitable physiotherapy in the form
of exercises and heat/cold as was indicated. In those cases with hemarthrosis
and traumatic synovitis of the knee, aspiration of the knee was done and a
compression bandage given.
OBSERVATIONS
The assessment was based on relief of symptoms against the number of days
of treatment.
|
Duration
of Treatment For Complete Relief |
|||
|
|
From Pain |
From Swelling |
From Tenderness |
|
Group I (R.Compound) |
5 days |
7 days |
7 days |
|
Group II (Oxphenbutazone) |
7 days |
7 days |
10 days |
|
Group III |
7 days |
10 days |
14 days |
Complete
relief from pain was noted within 3-7 days in patients receiving oxyphenbutazone
and aspirin; whereas the patients receiving R. Compound have noted complete
relief from pain within 3-5 days.
The swelling persisted particularly in
sprains and contusions after 1-week treatment with aspirin; whereas in
patients receiving oxyphenbutazone or R, Compound, the swelling disappeared
within 7 days.
Tenderness over
the sprained and contused part disappeared within the first week in those
receiving R. Compound. In the group receiving oxyphenbutazone, tenderness
lasted for 7 - 10 days and in the aspirin group, it persisted in some patients
even upto 14 days.
SIDE EFFECTS
No harmful side effects were noted in the
group treated with R, Compound. However, one patient complained about its
pungent smell. Both the other groups had shown some gastric irritation and
heart burn.
CONCLUSION
i)
The anti-infammatory and
analgesiaprop- erties of R. Compound (Alarsin) is comparable
to that of oxyphenbutazone and definitely superior to that of aspirin.
ii)
R. Compound is not
associated with any gastric irritation or any other side effects. Only
one patient in ten complained about its pungent smell.
iii)
R. Compound is
well-tolerated and economical.
ACKNOWLEDGEMENT
I thank Dr. V. Chacko Prof, of Orthopedics for
his valuable suggestions in preparing this paper, I am grateful to the Dean,
Kasturba Medical College, Manipal, for allowing me to conduct this trial and to
write this paper.
REFERENCES
1. H.VSardesai and S.S Deshpande: use of
R.Compound in Rheumatic arthritis: proceedings of the First Congress of the
S.E.A.P.A.L.A.R. Ed. ShantilalJ.Shah and members: Indian Rheumatism
Association, Bombay, P.P. 131-135.