Dr. L V Raghava

Dr L V Raghava

R. COMPOUND V/S Oxyphenbutazone Aspirin

Tenderness over the sprained and contused part disappeared within the 1st week in those receiving  
R. Compound. In the group receiving oxyphenbutazone, tenderness lasted for 7-­10 days. In aspirin receiving group it persisted in some patients even upto 14 days.
R. Compound is not associated with any gastric irritation or any other side effects. Both the other groups had shown gastric irritation and heartburn.

a Clinical Trial of R.Compound
Dr. L.V. Raghava Rao, M.S.,
Assistant Prof. in Orthopaedics
Kasturba Medical College, Manipal (Karnataka)

Paper at : Karnataka Orthopaedic Conference, Manipal, Feb. 1976

Acute soft tissue trauma in the form of sprains and contusions is of very common occurrence. Numerous anti-inflammatories, analgesic drugs are available, ranging from the basic aspirin to the phenylbutazone group, indomethacin and ibuprofen, with their corres­ponding side effects. The Ayurvedic durg,
R. Compound (Alarsin) is said to be having anti-inflammatory and analgesic activities com­parable to hydrocortisone and butazolidine without any toxic effects even on prolonged use.

The present trial is designed to study the anti-inflammatory & analgesic properties of R. Compound as compared to two other com­monly used anti-inflammatory & analgesic drugs, oxyphenbutazone and aspirin.


Thirty ambulatories otherwise healthy pa­tients with acute soft tissue trauma in the form of sprains, contusions, hemarthrosis knee and traumatic synovitis were selected for this study, from the out-patient Department of K.M.C. Hospital, Manipal. There were 18 men and 12 women. All these cases were radiolog­ically studied to eliminate any fractures. These patients were divided into three groups of 10 each. Group I patients received R. Compound at a dose of 1 tab/three times a day. Group II patients received oxyphenbutazone (Tanderil - Geigy, Oxyrin - Themis) at a dose of 1 tab/ tds. Group III patients received Aspirin at adose of 2 tab/tds. Side effects if any were noted. In all these cases, treatment was insti­tuted within 18 hours. (None of these cases had any associated diseases).

Sprains around the ankle         -           8
Sprains of wrist                       -           4
Hemarthrosis, knee                 -           3
Traumatic Synovitis                -           4
Contusions                              -           11
                                    TOTAL          30

All these cases were advised to take suita­ble physiotherapy in the form of exercises and heat/cold as was indicated. In those cases with hemarthrosis and traumatic synovitis of the knee, aspiration of the knee was done and a compression bandage given.


The assessment was based on relief of symptoms against the number of days of treatment.

Duration of Treatment For Complete Relief


From Pain

From Swelling

From Tenderness

Group I (R.Compound)

5 days

7 days

7 days

Group II (Oxphenbutazone)

7 days

7 days

10 days

Group III

7 days

10 days

14 days


Complete relief from pain was noted within 3-7 days in patients receiving oxyphen­butazone and aspirin; whereas the patients receiving R. Compound have noted complete relief from pain within 3-5 days.
The swelling persisted particularly in sp­rains and contusions after 1-week treatment with aspirin; whereas in patients receiving oxyphenbutazone or R, Compound, the swel­ling disappeared within 7 days.

Tenderness over the sprained and con­tused part disappeared within the first week in those receiving R. Compound. In the group receiving oxyphenbutazone, tenderness lasted for 7 - 10 days and in the aspirin group, it persisted in some patients even upto 14 days.


No harmful side effects were noted in the group treated with R, Compound. However, one patient complained about its pungent smell. Both the other groups had shown some gastric irritation and heart burn.


i)              The anti-infammatory and analgesiaprop- erties of R. Compound (Alarsin) is com­parable
to that of oxyphenbutazone and definitely superior to that of aspirin.

ii)             R. Compound is not associated with any gastric irritation or any other side effects. Only
one patient in ten complained about its pungent smell.

iii)            R. Compound is well-tolerated and economical.


I thank Dr. V. Chacko Prof, of Orthopedics for his valuable suggestions in preparing this paper, I am grateful to the Dean, Kasturba Medical College, Manipal, for allowing me to conduct this trial and to write this paper.


1. H.VSardesai and S.S Deshpande: use of R.Compound in Rheumatic arthritis: proceedings of the First Congress of the S.E.A.P.A.L.A.R. Ed. ShantilalJ.Shah and members: Indian Rheumatism Association, Bombay, P.P. 131-135.